The first dissolution surveillance system.

With a unique design and powerful software the dissoGUARD® is a dissolution surveillance system that will revolutionize the way you see the dissolution procedure. With cameras placed underneath a dissolution bath the user is not only able to see and store real time videos, export pictures or complete videos for future analyses, but we also took a step forward. For the first time, the user is able to measure or predict different physical parameters of their dissolution apparatus. With different algorithms the software can evaluate the wobble and measure RPM, determine the proper center alignment of individual shafts, and much more. Through the various stages of dissolution procedure it is possible to evaluate the proper position of dosage forms, timing and position of sampling cannulas, behavior of particles in vessels, etc. This product is not meant to be a qualification tool but it can dramatically improve the control over your dissolution apparatus. It can guard your dissolution procedure before and during every single run preventing you from having questions like:

Do YOU know, what is happening with your Dissolution Apparatus between periodical OQ/MQs?

What do YOU do if periodical OQ/MQ fails?

Were the timings and position of manual sampling correct?

Were baskets placed properly in the last run?


The difference between dissoGUARD® and dissoGUARD® PRO

The main function of dissoGUARD® and dissoGUARD® PRO is life preview of video for six or seven vessels in dissolution system. Both are capable of recording and playback of specified duration. In dissoGuard PRO version the capability of measurement is added.


The basic model is a simple recorder. With some unique features such as motion detector and LED illumination it is able to record good quality videos for six vessels. With optional easy to install light shield around the bath and adaptive LED illumination it is an ideal system for applications that are visible light sensitive. After the recording is taken the user is able to pinpoint and mark individual stages of the dissolution procedure. Because of the unique cameras position different operations are well visible (tablets drop or baskets immersion, sampling cannula or temperature probe immersion). The timing of different events can be determined down to seconds.


The PRO version is an ultimate guardian for the dissolution procedure and apparatus. The dissoGUARD® PRO is not meant to be a Qualification tool, but it will keep you on the safe side during periodical OQ/MQ measurements. With unique software algorithms excessive wobble for individual basket or paddle can now be successfully predicted. Measuring of individual paddle speed of rotation (RPM) is possible from the video itself. Proper centering of vessels and shafts can be checked. Software is able to warn a user about status of a run. Once the system is installed it will run almost automatically. After the recording is taken the user is able to pinpoint and mark individual stages of the dissolution procedure. The timing of different events (tablets drop or baskets immersion, sampling cannulas or temperature sensors immersion) can be determined down to seconds.

System Functionality Overview



How to use RPM measurements (available only in dissoGUARD® PRO)?

By clicking and activating the RPM button, the measurement of rotation per minute (RPM) will be activated and the user will notice a RPM: written in all positions. The measurement of RPM only works with stainless steel paddles and is measured for each individual paddle separately. If the baskets are used, the function is still active on systems equipped with the optional 7th camera. In this case, the paddle should be fitted in position 7 of the dissolution, and consequently the RPM measurement is only active in position 7.

How to use Wobble detection function (available only in dissoGUARD® PRO)?

The Wobble detection function is a simple but very effective way to quickly determine the excessive wobble of an individual basket or paddle. Once the function is activated, the linear video of a basket/paddle rim will be displayed on the bottom of every video. When the paddle or basket is rotating, the wobble will be shown as a wave in the linear video. For wobble close to 0mm, the user should see a flat line of a rim. The height of a linear video should be set to represent a total of 2mm of actual video size. That means that once the wobble is near the upper limit, the rim will touch or exceed the linear video. That gives the user information that the wobble might be excessive.

How to predict inappropriate height of paddles/baskets (available only in dissoGUARD® PRO)?

The Wobble function is also very sensitive to the appropriate height of paddles/baskets. If you are not able to see a rim of the paddle or the basket in the linear video (or if it shifted from the center of the linear video), that means the height is misaligned. Recheck the height of paddles or baskets.

How to use Motion detection function (available only in dissoGUARD® PRO)?

By clicking and activating the Motion function, you will notice the red/green dot in the upper left corner of an individual position. The main purpose of Motion detection function is to detect the sudden stop of one or more paddles/baskets. If that happens during the run and the recording is active, the red dot will be displayed in the playback panel. The red dot represents the Error in the playback panel. The function will also detect the end of a run.

Setting and using the Center option (available only in dissoGUARD® PRO)?

By clicking and activating the Center button, the center grid lines and center circle is displayed with individual videos. If the function is activated, it will also be recorded to the video stream. The selection of Apparatus 1 (baskets) or Apparatus 2 (paddles) also has an effect on the Center function. The difference is in the radius of the center circle. The circle should fit to the paddle shaft diameter or basket rim.

Do you need a PC with the dissoGUARD?

Yes, the dissoGUARD is controlled with dedicated software. It has to be a desktop PC fitted with interface FireWire cards (provided with the dissoGUARD). For additional information, please, contact your local provider.

How far away can PC be from a dissoGUARD?

The length of cables that is provided with the dissoGUARD is 3m (10ft). With additional cable extension kit, the distance can be extended to 10m (33ft).

Is there an Installation Qualification (IQ) protocol available for the dissoGUARD?

YES. We provide an Installation Qualification (IQ) document that covers the installation of software and hardware equipment.

Can the dissoGUARD be used for qualification of the dissolution (OQ, EMQ)?

NO. The purpose of measurements of all physical parameters is for control purposes only. All measurements (RPM, wobble and shaft center) are only meant to be an assistance to the user. Because it is fast and efficient, the evaluation of some physical parameters can be done daily or before each dissolution run. If the user suspects an error, Qualification procedure is advised with qualified measuring equipment.

Does the dissoGUARD need a qualification (OQ)?

NO. No data is recorded. Values can be seen on recorded video itself for check purposes only. That is why we do not provide an OQ documentation or procedure for the dissoGUARD.

Available for
Agilent Technologies 708-DS, 709-DS
Hanson Vision Classic 6, Vision Elite 8, SR-8
For other models please contact us.


The dissoSWITCH®

is a simple valve box with 16 three-way valves and up to 25-pin electric connection switches. Valves are used to redirect sample paths and are carefully chosen to sustain the most demanding solutions.
It is possible to redirect communication paths between different systems (PCs, autosamplers, dissolutions etc.) with an electric switch. The switch is controlled with single button. Long press is used for turning the switch ON and OFF. Short press is used to switch between System 1 and System 2. The displayed name on the switch can be user-programmed. Different cable adapters can be purchased to meet your specific piece of equipment. Contact us for more details.
Possible solutions:
- Bypassing spectrophotometer flow cells (saves spectrophotometer flow cells).
- Redirecting sample lines to spectrophotometer and autosampler (saves spectrophotometer flow cells, shorter sample path).
- Connecting and driving two dissolutions with one autosampler.
- Many possibilities in combination with spectrophotometers, autosamplers or PCs.
- Bypassing filter changer, manual filters, etc.



The dissoSHIELD®

is a high quality protection that stops ambient light reaching a light sensitive dosage forms inside vessels. It is an alternative to amber vessels, with a few benefits. With its unique design it allows for user to still see the process by opening each of the three doors. The usage of camera system dissoGUARD® is also possible and it allows a perfect visibility even for light sensitive dosage forms. For non-light sensitive products, the front door can be completely removed. In that case, full visibility is reached.


Keep In Touch

You can always keep in touch with fill form below and send a message to us!


Merel d.o.o.
Ob gozdu 25
SI-2352 Selnica ob Dravi

Office: Limbuška cesta 42, 2000 Maribor, Slovenia

Phone: +386 2 229 73 90
Fax: +386 2 229 73 91